*Miki Ohta¹, Rika Okamoto², Kimie Sai³, Takuya Imatoh⁴, Susumu Wakabayashi^5,8, Shoko Suzuki⁶, Susumu Ogawa⁷, Ryoma Seto⁸, Noriaki Arakawa³ (1. The University of Tokyo Hospital, 2. Translational Research Center for Medical Innovation, Foundation for Biomedical Research and Innovation at Kobe, 3. National Institute of Health Sciences, 4. Faculty of Pharmaceutical Sciences, Fukuoka University, 5. Kyorin University Hospital, 6. International Institute for Advanced Studies, 7. Pharmaceutical Safety Bureau, Ministry of Health, Labour and Welfare, 8. Faculty of Healthcare, Tokyo Healthcare University)

*Susumu Ogawa¹, Haruka Iwai¹, Yumiko Nomura¹ (1. Pharmaceutical Safety Bureau, Ministry of Health, Labour and Welfare)

*Kimie Sai¹ (1. National Insititute of Health Sciences)

*Takuya Imatoh¹ (1. Faculty of Pharmaceutical Sciences, Fukuoka University)

*Miki Ohta¹, Rika Okamoto² (1. The University of Tokyo Hospital, 2. Translational Research Center for Medical Innovation, Foundation for Biomedical Research and Innovation at Kobe)

*Rika Okamoto¹ (1. Translational Research Center for Medical Innovation)

*Susumu Wakabayashi^1,2, Ryoma Seto² (1. Kyorin University Hospital, 2. Faculty of Healthcare, Tokyo Healthcare University)

Hideto Yokoi¹, Daisuke Koide², Kohei Takahashi³, *Fumiaki Mikami¹, Hironobu Minai⁴, Ayako Yagahara⁵ (1. Kagawa University Hospital, 2. Graduate School of Medicine, The University of Tokyo, 3. Chiba University Hospital, 4. Jokoh Co., Ltd., 5. Faculty of Health Sciences, Hokkaido University of Science)

*Hideto Yokoi^1,2 (1. Department of Medical Informatics, Kagawa University Hospital, 2. Clinical Research Support Center, Kagawa University Hospital)

*Daisuke Koide¹ (1. Dept.of Biostatistics & Bioinformatics, Grad. of Med, The Univ. of Tokyo)

*Ayako Yagahara¹ (1. Hokkaido University of Science)

*Fumiaki Mikami¹, Hideto Yokoi¹ (1. Kagawa University Hospital)

*Hironobu Minai¹ (1. Jokoh Co., Ltd.)

*Kohei Takahashi¹, Daisuke Koide², Hideto Yokoi³ (1. Clinical Research Center Chiba University Hospital, 2. Department of Biostatistics and Bioinformatics Graduate School of Medicine Faculty od Medicine, 3. Department of Medical Informatics Clinical Research Support Center)

*Mihoko Okada¹, Masaho Ishino², Mitsuyoshi Yoshimoto³, Kouta Funakoshi⁴, Satoshi Ueno⁵, Kazuhito Satou⁶ (1. Institute of Health Data Infrastructure for All, 2. Sapporo Medical University Collaboration Center for Community and Industry, 3. Exploratory Oncology Research & Clinical Trial Center, National Cancer Center Japan, 4. Center for Clinical and Translational Research, Kyushu University Hospital, 5. Center for Health Informatics Policy, National Institute of Public Health, 6. Japan Agency for Medical Research and Development)

*Masaho Ishino¹ (1. Sapporo Medical University School of Medicine)

*Mitsuyoshi Yoshimoto¹ (1. National Cancer Center)

*Kouta Funakoshi¹ (1. Center for Clinical and Translational Research, Kyushu University Hospital)

*Satoshi Ueno¹ (1. National Institute of Public Health)

*Kazuhito Satou¹ (1. Japan Agency for Medical Research and Development)