[MO-31] Factors associated with Cardio Ankle Vascular Index (CAVI) in community dwelling individuals
Cardio Ankle Vascular Index (CAVI) in an index for arterial stiffness and atherosclerosis. Role of different atherosclerotic risk factors on CAVI is not clear in the community dwelling individuals. This study aims to evaluate the association of different Cardiovascular Disease (CVD) risk factors on CAVI. Participants from a prospective cohort study have been recruited for CAVI measurement. People with abnormal Ankle Brachial Index (ABI), chronic kidney disease, cancer and hepatitis have been excluded from the study. Known risk factors for atherosclerosis were assessed in the individuals. Univariate analysis showed that CAVI is significantly correlated with age, Systolic blood pressure, diastolic blood pressure, blood urea nitrogen (BUN), Glycated hemoglobin (HBA1c) and Generalized Anxiety Disorder index (GAD), with Pearson correlation coefficient of 0.57, 0.30, 0.18, 0.20, 0.21, -0.15 respectively (all p values <0.05). Multivariate analysis showed that age, BMI and ABI are the independent determinants of CAVI. And only age (OR=1.194, CI=1.097-1.3) and BMI (OR=0.794, CI=0.667-0.946) are independent determinants of high CAVI. CAVI is a reliable index for atherosclerosis, as it is not dependent on the known risk factors for CVD. Suggestions about weight reduction can be considered an important factor if we want to tackle high arterial stiffness to reduce CVD burden.