[ES3-01] What is new on LUTS/Nocturia from Okinawa/Japan?
[Biography]1993 MD; graduate from Ryukyu University, School of Medicine
2004 PhD; University of the Ryukyus
2006-2008: Postdoctoral associate, Department of Urology, University of Pittsburgh School of Medicine, USA (PI, prof. Yoshimura)
2015 Associate professor, Department of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
2019 Professor, Department of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Aging leads to complicated changes in bladder and urethral activity. We have previously reported that aging was assumed to induce dysfunction in nitric oxide (NO)-mediated urethral smooth muscle relaxation with an increase of oxidative stress markers in the urethra, and that application of a NO donor and a stimulator of soluble guanylyl cyclase (sGC) could restore impaired urethral smooth muscle relaxation. Thus, age-associated ischemic and oxidative stress in the urethra might be correlated with impairment of the NO/sGC system and with coordination of the bladder and urethra. Now we are now ongoing to restore age-related irreversible changes in coordination of the bladder and urethra by low-intensity extracorporeal shock wave therapy (LiESWT). Furthermore, aging is associated with lower urinary tract symptoms, such as nocturia, resulting in increased health problems. We recently developed the digital self-health monitoring system of urine excretion (s-HMSU), as an alternative to frequency volume chart, in Kumejima Digital Health Project (KDHP). In this project, we ascertained that nocturia and shortened hours of undisturbed sleep could be signs of obesity/ metabolic syndrome. Now we are ongoing to develop app recording nocturia and shortened hours of undisturbed sleep with feedback. In this session, I will introduce what is going on to develop genesis of aging urethra and possibility of a sensing of nocturia as obesity/ metabolic syndrome?
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