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[BAO01-09] Epimerization of oligopeptides induced by radiation rays
Keywords:epimerization, oligopeptides, gamma rays
Linear and cyclic alanine dipeptides were irradiated in solution or as solid state by gamma rays (1-24 kGy). The resulted reaction solutions were analyzed by means of HPLC equipped with achiral or chiral columns. Linear L-Ala-L-Ala epimerized faster (reaction rate constant: 0.017kGy-1) than D-Ala-L-Ala (0.0033kGy-1) in 1mM solutions. This suggests that such reaction conditions are not suited for accumulation of homochiral peptides. However, the results in the reactions using cyclic dipeptides showed heterochiral peptides epimerizes faster than homochiral peptides.