2:15 PM - 2:30 PM
[BCG09-03] Lysine polymerization on amorphous silica: A thermodynamic evaluation
Keywords:Adsorption, Lysine, Silica
This study focuses on thermodynamic effects of minerals on amino acid polymerization. To date, widely various oxide minerals and clays has been examined for their roles in this reaction (Cleaves et al., 2012). Results have demonstrated their positive influences with regard to reaction rate, peptide length, and the amounts of polymers synthesized. However, reported experiments have mostly emphasized catalytic properties of minerals. Consequently, in most cases, experiments have been terminated before polymerization reaches its steady state. It remains unclear whether minerals promote polymerization in thermodynamics as well as kinetics.
To examine the thermodynamic effects, we have evaluated adsorption behaviors of amino acids and peptides on minerals by using extended triple layer model (ETLM; Sverjensky and Fukushi, 2006). Obtained adsorption parameters are used, by combining thermodynamic parameters for amino acids and peptides in aqueous solution, to predict amino acid/peptide equilibria on mineral surfaces. In this presentation, we will present our findings for a lysine/amorphous silica system.