Japan Geoscience Union Meeting 2019

Presentation information

[J] Oral

M (Multidisciplinary and Interdisciplinary) » M-IS Intersection

[M-IS10] Interface- and nano-phenomena on crystal growth and dissolution

Tue. May 28, 2019 9:00 AM - 10:30 AM 303 (3F)

convener:Yuki Kimura(Institute of Low Temperature Science, Hokkaido University), Hitoshi Miura(Graduate School of Natural Sciences, Department of Information and Basic Science, Nagoya City University), Hisao Satoh(Naka Energy Research Laboratory, Mitsubishi Materials Corporation), Katsuo Tsukamoto(Graduate School of Engineering, Osaka University), Chairperson:Yuki Kimura (Institute of Low Temperature Science, Hokkaido University)

9:00 AM - 9:15 AM

[MIS10-01] Fabrication of octacalcium phosphate block through a dissolutionprecipitation
reaction and its biological evaluation

*Yuki Sugiura1, Munar L Melvin2, Kunio Ishikawa2 (1.National Institute of Advanced Industrial Science and Technology, 2.Kyushu University)

Keywords:Calcium phosphate, bone substitute, biomaterial

Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0 ± 0.2 MPa. The macroporosity and microporosity of the OCP block were 33.4 ± 4.5% and, 69.0 ± 1.6%, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and ~30% of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes.