[MIS23-07] Fabrication of Ag substituted octacalcium phosphate with antibacterial property and its biological evaluation
Keywords:calcium phosphate, antibacterium agent, bone substitute, crystal engineering
Ag is a classical antibacterium agent, then, it widely used. Although various studies investigated how attach Ag to bone substitute, free Ag ions make bone substitute to change color to blacky. This is an serious drawback for oral usage.
We have been investigating the effect of cationic ions for OCP substitution. Then, their ionic radii is an important factor for substitution. When the ionic radius of cation is similar to that of Ca, these ions could be substituted to OCP unit lattice. The ionic radius of Ag it ~1.00A, which is as same as that of Ca. Based on this knowledge, we fabricated Ag substituted OCP (OCP-Ag). When fabricated OCP-Ag immersed into medium, no color change was observed. In addition, OCP-Ag exhibited excellent antibacterium properties of oral bacterias such as S. mutans, E. coli and S. aureus. In this presentation, we would like to introduce how fabricate OCP-Ag and its biological properties.