*Mitsuki Kondo¹, Yoshinori Ikenaka^1,2,3,4, Shouta MM NAKAYAMA^1,5, Kawai K Yusuke⁶, Mayumi Ishizuka¹ (1.Laboratory of Toxicology, Department of Environmental Veterinary Science, Graduate school of Veterinary Medicine, Hokkaido University, 2.Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa, 3.Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, 4.One Health Research Center, Hokkaido University, 5.Biomedical Sciences Department, School of Veterinary Medicine, The University of Zambia, 6.Laboratory of Toxicology, Division of Veterinary Science, Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine )