[EO-21] The effect of incorporating nano-porous silica particles on the viscoelastic behavior of a commercial tissue conditioner and its long-lasting drug-release characteristics
[Abstract]
[Objective]
Tissue conditioners expedite tissue healing in denture patients, playing a vital role in the overall effectiveness of tissue repair1,2). However, traditional tissue conditioners do have limitations such as limited durability, infections, susceptibility to colonization by microorganisms, and hygiene concerns. These factors can impact their effectiveness and the oral health of the patient if not properly managed. On the other hand, the high surface area of nano-porous silica, selectivity in adsorption, and low toxicity, nano-porous silica has been extensively employed for adsorbing toxic molecules and in drug delivery systems. This research aims to present a new silica-enhanced drug-infused tissue conditioner as a promising strategy to improve the efficiency and durability of prosthetic dentures.
[Method]
Samples were made using stainless-steel molds, stored in water at 37°C, and evaluated for viscoelasticity over different periods. Two groups were tested: the commercial tissue conditioner (Shofu Tissue Conditioner II) and the novel one. The shear storage modulus (G’), shear loss modulus (G”), and loss tangent (tan δ) were measured. The drug-loaded technique was applied using nano-porous silica as the carrier with a specified pore size. Cetyl pyridinium chloride was used as an antibacterial agent.
[Results and Discussion]
The drug delivery findings revealed that the inclusion of silica with a nanoporous structure in tissue conditioner can demonstrate absorption/controlled release properties for the drug carrier. Additionally, the results indicated the potential of silica to serve as an ideal drug carrier material in silica-enhanced tissue conditioners. Mechanical tests confirmed that there is no significant difference in the viscoelasticity of silica-added tissue conditioner compared to pure tissue conditioner. Drug-loaded tissue conditioners represent an innovative and promising advancement in oral health, particularly for prosthodontic applications, offering benefits such as improved healing, infection prevention, pain relief, and enhanced patient comfort.
[References]
1) Murata H, Chimori H, Hong G, et al. Compatibility of tissue conditioners and denture cleansers: Influence on surface conditions. Dent Mater J 2010;29:446-53
2) Murata H, Chimori H, Hamada T, et al. Viscoelasticity of dental tissue conditioners during the sol-gel transition. J Dent Res 2005;84:376-81
[Objective]
Tissue conditioners expedite tissue healing in denture patients, playing a vital role in the overall effectiveness of tissue repair1,2). However, traditional tissue conditioners do have limitations such as limited durability, infections, susceptibility to colonization by microorganisms, and hygiene concerns. These factors can impact their effectiveness and the oral health of the patient if not properly managed. On the other hand, the high surface area of nano-porous silica, selectivity in adsorption, and low toxicity, nano-porous silica has been extensively employed for adsorbing toxic molecules and in drug delivery systems. This research aims to present a new silica-enhanced drug-infused tissue conditioner as a promising strategy to improve the efficiency and durability of prosthetic dentures.
[Method]
Samples were made using stainless-steel molds, stored in water at 37°C, and evaluated for viscoelasticity over different periods. Two groups were tested: the commercial tissue conditioner (Shofu Tissue Conditioner II) and the novel one. The shear storage modulus (G’), shear loss modulus (G”), and loss tangent (tan δ) were measured. The drug-loaded technique was applied using nano-porous silica as the carrier with a specified pore size. Cetyl pyridinium chloride was used as an antibacterial agent.
[Results and Discussion]
The drug delivery findings revealed that the inclusion of silica with a nanoporous structure in tissue conditioner can demonstrate absorption/controlled release properties for the drug carrier. Additionally, the results indicated the potential of silica to serve as an ideal drug carrier material in silica-enhanced tissue conditioners. Mechanical tests confirmed that there is no significant difference in the viscoelasticity of silica-added tissue conditioner compared to pure tissue conditioner. Drug-loaded tissue conditioners represent an innovative and promising advancement in oral health, particularly for prosthodontic applications, offering benefits such as improved healing, infection prevention, pain relief, and enhanced patient comfort.
[References]
1) Murata H, Chimori H, Hong G, et al. Compatibility of tissue conditioners and denture cleansers: Influence on surface conditions. Dent Mater J 2010;29:446-53
2) Murata H, Chimori H, Hamada T, et al. Viscoelasticity of dental tissue conditioners during the sol-gel transition. J Dent Res 2005;84:376-81