[HIRANUMA-11] Effect of etching time on titanium dental implants with alumunium oxide (AL2O3) coating on hemolysis percentage and platelet activation
[Abstract]
Titanium is the most widely used dental implant material. Titanium require surface modification to improve osseointegration. Coating implants with Al2O3 leaves alumina residue and etching implants with HCl 37% can prevent the contamination. This study examines the effect of etching time on titanium dental implants with Al2O3 on hemolysis percentage and platelet activation.
Experimental studies were conducted on titanium dental implants (Ø=4 mm; l=12 mm) treated with Al2O3 and HCl 37%. A total of 24 samples were divided into 4 groups: group 1 (Al2O3), group 2 (Al2O3 + 5 minutes etch), group 3 (Al2O3 + 10 minutes etch), and group 4 (Al2O3 + 20 minutes etch). Percentage hemolysis and platelet activation was measured using hematology analyzer, CD41, and CD62P expression. The data obtained were analyzed using one-way ANOVA.
The one-way ANOVA test showed that there was a significant effect (p<0.05). The post hoc LSD test showed a significant difference in the mean hemolysis percentage and platelet activation for all groups (p<0.05), except the etching group at 5 and 20 minutes. The conclusion is the etching time on titanium dental implants with Al2O3 coating has an effect on reducing the hemolysis percentage and increasing the platelet activation, with the optimum time is 10 minutes.
トピックス
●dental implant
●hemolysis
●platelet activation
Titanium is the most widely used dental implant material. Titanium require surface modification to improve osseointegration. Coating implants with Al2O3 leaves alumina residue and etching implants with HCl 37% can prevent the contamination. This study examines the effect of etching time on titanium dental implants with Al2O3 on hemolysis percentage and platelet activation.
Experimental studies were conducted on titanium dental implants (Ø=4 mm; l=12 mm) treated with Al2O3 and HCl 37%. A total of 24 samples were divided into 4 groups: group 1 (Al2O3), group 2 (Al2O3 + 5 minutes etch), group 3 (Al2O3 + 10 minutes etch), and group 4 (Al2O3 + 20 minutes etch). Percentage hemolysis and platelet activation was measured using hematology analyzer, CD41, and CD62P expression. The data obtained were analyzed using one-way ANOVA.
The one-way ANOVA test showed that there was a significant effect (p<0.05). The post hoc LSD test showed a significant difference in the mean hemolysis percentage and platelet activation for all groups (p<0.05), except the etching group at 5 and 20 minutes. The conclusion is the etching time on titanium dental implants with Al2O3 coating has an effect on reducing the hemolysis percentage and increasing the platelet activation, with the optimum time is 10 minutes.
トピックス
●dental implant
●hemolysis
●platelet activation