[2F4] [General Session] 4. Knowledge Utilization and Sharing

[2F4-01] Ontology-based Knowledge Systemization for Interpreting the Mechanism of Liver Toxicity

オントロジー工学に基づく機序解釈支援に向けて

〇Yuki Yamagata¹, Yoshinobu Igarashi¹, Noriyuki Nakatsu¹, Katsuhisa Horimoto², Kazuhiko Fukui², Yoshihiro Uesawa³, Hiroshi Yamada¹ (1. National Institutes of Biomedical Innovation, Health and Nutrition, 2. National Institute of Advanced Industrial Science and Technology, 3. Meiji Pharmaceutical University)

Keywords:Ontology, Liver toxicity, Safety assessment, Drug development

To understand the mechanisms of drug-induced liver injury, we have developed an ontological model for the liver toxicity. In this paper, we focus on safety assessment and propose an application system based on the ontology and the semantic web technology.