[3H5-OS-10c] OS-10

[3H5-OS-10c-05] Estimated Method of Metastasis Factors on Pancreatic Cancer using Extended PCA Components and Gene Mutations Distribution

〇Yohko Konno¹ (1. Hokkaido University)

[[Online]]

Keywords:cancer, mutation, metastasis, Factor, PCA

Pancreatic Cancer is one of intractable cancer. The important factor in the judgment of progress in metastases and genetic mutation. The metastasis is considered how to find the sign. In this model, variational autencoder and decision tree, principal component analysis are researched using public cancer database. The causes of metastasis from the perspective of gene mutations is investigated. Pancreatic cancer metastasis is often caused by gene mutations to the liver accompanied by KRAS and TP53, and the analysis results show that the incidence rate is approximately 60% and 55% in cases with OS of less than 1 year. In addition to KRAS, the expression of TP53 and CDKN2A is involved in predicting metastasis. In addition, to extend survival time, it's suggested that the number of metastatic sites is 1 or less, or even if it is 1 or more, the age of metastasis is less than 60 years old.