[13p-PB4-1~10] 12.6 Nanobiotechnology

[13p-PB4-8] Development of Peptide-MOF Chemical Motors that Detect Target Materials

〇Yasuhiro Ikezoe^1,2, Justin Fang², Tomas L. Wasik², Menglu Shi², Uemura Takashi^4,5, Kitagawa Susumu^4,6, Matsui Hiroshi^2,3 (1.NIT, 2.CUNY, Hunter College, 3.Cornell Univ., 4.Kyoto Univ., 5.CREST-JST, 6.iCeMS)

Keywords:peptide,MOF,chemical motor

We have developed new peptide-MOF motors that can sense the location of PbSe targets and swim toward them with the aid of Pb-binding urease. The pH gradient created around the targets with the urease guides the motion of peptide-MOF motors and the chemical motor completes the movement as they reach to the targets. Such behavior resembles the movement of living organisms toward a chemical attractant. The chemotactic motor translating the chemical power of nanoscale self-assembly into the motion of macroscopic objects in a millimeter scale with high velocity over distance of several centimeters is an interesting system. In future, it is desirable to program peptide-MOF motor systems for directly sensing concentration gradient of chemicals like chemotaxis.