9:30 AM - 11:30 AM
▲ [14a-PB1-9] The Antimicrobial Effect against a variety of bacterial species Induced By Reactive Oxygen Species Generated From Photo-Functional Polymer
Keywords:Reactive oxygen species,photofunctional polymer,antimicrobial
Reactive oxygen species (ROS) have been a long time subject in chemical, environmental, and bio-medical science due to its strong reactivity and selectivity, and the involvement with metabolism of cell and organs1. They have many applications such as photodynamic cancer therapy, decontamination of blood product, water disinfectant, drug delivery system, and stereo-selective synthesis of drug in life science area2. Therefore, investigation on the photosensitizers with high efficiency of ROS generation is in a great demand3.
In this study, we report antimicrobial effect of the photofunctional polymer. The photofunctional polymer (PFP) that is the polymer embedded with a photosensitizer is fabricated by a simple solvent swell-encapsulation-shrink method. Reactive oxygen species(ROS) generation from PFP is confirmed with photocatalysis test. And Singlet oxygen generation from PFP is directly confirmed with time and wavelength resolved singlet oxygen phosphorescence spectroscopy. For the influence study of reactive oxygen species (ROS), photodynamic inactivation (PDI) effect of photofunctional polymer is evaluated for various derivative gram-negative bacteria and super bacteria.
In this study, we report antimicrobial effect of the photofunctional polymer. The photofunctional polymer (PFP) that is the polymer embedded with a photosensitizer is fabricated by a simple solvent swell-encapsulation-shrink method. Reactive oxygen species(ROS) generation from PFP is confirmed with photocatalysis test. And Singlet oxygen generation from PFP is directly confirmed with time and wavelength resolved singlet oxygen phosphorescence spectroscopy. For the influence study of reactive oxygen species (ROS), photodynamic inactivation (PDI) effect of photofunctional polymer is evaluated for various derivative gram-negative bacteria and super bacteria.