[16a-2C-1~9] 4.2 Bio- and Medical Photonics

▲ [16a-2C-6] Multimodal label-free measurements for diagnostics of live cellular samples

〇(P)Nicolas Pavillon¹, Nicholas Smith¹ (1.Osaka Univ.)

Keywords:Live cell measurement,Raman microscopy,Quantitative phase imaging

Label-free measurements enable the observation of samples without requiring additional processing steps as for example loading contrast agents or cell fixation, enabling direct measurement of live samples. We present here multimodal label-free analysis of live cells based on both Raman spectroscopic measurements and quantitative phase microscopy (QPM), and present analysis approaches to derive relevant biological information from the combination of the two types of data, namely Raman spectroscopy and morphological/dynamic measurements from QPM.