4:00 PM - 4:30 PM
[13p-D63-1] [INVITED] Controllable Protein Aggregation with Ultrasonic Irradiation for Early Diagnostics of Neurodegenerative Diseases
Keywords:ultrasonics, Alzheimer disease, cavitation
Transformation from monomers to aggregates in amyloidosis proteins is deeply related to pathogenic mechanisms of neurodegenerative diseases such as Alzheimer's disease. Acceleration of protein aggregation reaction is a long-running problem in the drug development and early diagnosis. We recently found that ultrasonic cavitation bubbles behave as catalysts for nucleation for aggregation of proteins; by optimizing ultrasonic frequency and pressure, the reaction-rate constant for aggregation is increased by nearly three-orders-of magnitudes for amyloid beta peptide, for example. In this talk, the ultrasonically accelerated protein aggregation is explained with its mechanism, and its application to the early diagnostics is discussed.