[15p-C31-1~9] 4.2 Bio-and Medical Photonics

▲ [15p-C31-2] Surface-enhanced Raman spectroscopic analysis of the cyclic Arg–Gly–Asp peptide ligands of cells using plasmonic nanogap antennas

〇Takaaki Yano¹, Alejandro Portela¹, Christian Santschi², Olivier Martin², Hitoshi Tabata³, Masahiko Hara¹ (1.Tokyo Tech., 2.EPFL, 3.Univ. Tokyo)

Keywords:Surface-enhanced Raman scattering (SERS), Cyclic RGD (cRGD) peptide ligands, Plasmonics

We report a highly sensitive spectroscopic analysis of the cyclic RGD (cRGD) peptide ligands of cells based on surface-enhanced Raman spectroscopy (SERS) using single plasmonic nanogap antennas in aqueous environment. The exhibited blinking of the SERS spectra and synchronization of intensity fluctuations, suggest that the SERS spectra acquired from single dimer nanogap antennas was dominated by the spectrum of single to a few molecules. SERS spectra of c(RGDfC) could be used to detect at the nanoscale, the cells’ transmembrane proteins binding to its ligand.