[19a-W323-1~12] 12.6 Nanobiotechnology

[19a-W323-3] Control and characterization of self-assembed process of biomolecular microstructures

〇Makoto Sakurai¹, Pradyot Koley¹, Masakazu Aono¹ (1.NIMS, MANA)

Keywords:self-assembly,peptide,hierarchical structure

Construction of functional biomolecular microstructures through self-assembly is of fundamental interest due to their various applications in nanomedicines and integrated devices. We report a new method of controlling and analyzing the self-assembly of a short peptide diphenylalanine. It is a simple model system to understand the formation of more complicated biomolecular hierarchical nano- and micro-structures. Morphological transitions from nanoscale spheres to porous microspheres and from simple microtubes to hierarchical ones were caused by the non-equilibrium artificial supersaturation during their growth. The in site monitoring of the self-assembled growth shows self-healing behavior and contribution from surface diffusion in the formation of the microtubes.