[20a-W323-1~12] 12.6 Nanobiotechnology

[20a-W323-11] Fluctuating Nanoscale Chain Structures Visualized by 3D-SFM in Liquid

〇Natsumi Inada¹, Kazufumi Takao¹, Hitoshi Asakawa^1,2, Takeshi Fukuma^1,2,3 (1.Kanazawa Univ., 2.Bio-AFM FRC, 3.JST ACT-C)

Keywords:AFM,self-assembled monolayer,oligo ethylene glycol

Nanoscale chain structures such as protein termini are distributed at solid/liquid interfaces. Direct visualization of their molecular-scale structures is difficult with any established methods. We aimed to investigate such nanoscale chain structures distributed at solid/liquid interfaces by three-dimensional scanning force microscopy (3D-SFM). However, it was difficult to understand the visualization mechanism of nanoscale chains in the obtained 3D-SFM images. In this study, we performed molecular dynamics calculation of interaction forces acting on the tip for revealing the visualization mechanism.