[21p-S422-1~19] 3.4 Biomedical optics

[21p-S422-15] Multi-wavelength Swept Interferometric Microscope for en-face Tomographic Vibration Measurement in Biological Tissue

〇Samuel Choi^1,3, Keita Sato¹, Fumiaki Nin^2,3, Hiroshi Hibino^2,3 (1.Department of Electrical and Electronics Engineering, Niigata Univ., 2.School of Medicine, Department of Molecular Physiology, Niigata Univ., 3.AMED-CREST, AMED)

Keywords:En-face optical coherence tomography,Biological vibration measurement,Mechanobiology

To address microvibrations occur in bio-tissues, multi-wavelength swept OCT utilizing wide-field heterodyne vibrometry has been developed. These arrangements allow obtaining not only 3D tomographic images but also surface vibration parameters such as spatial amplitude, phase, and frequency, over a wide field. Our system achieved the axial resolution of ~2.5 μm with measurable depth of 0.5 mm, and we captured vibrations of internal surfaces of bio-tissue at frequency of 1 – 10 kHz