[6p-A402-1~11] 3.4 Biomedical optics

▲ [6p-A402-5] Fungicidal response of a novel natural photosensitizer (Lawsonia Inermis L.) on Sporothrix schenckii and Microsporum fulvum with low-power laser radiation

Himanshu Bansal^1,3,4, 〇Sukhdev Roy^1,3,4, Janendra Srivastava^2,3,4 (1.Dept. of Physics, 2.Dept. of Botany, 3.Dayalbagh Ed. Inst., 4.Agra, India)

Keywords:Photodynamic therapy, Natural photosenitizer, Lawsonia Inermis L.

We have shown the potential of an aquous extract of Lawsonia Inermis L. as a natural photosensitizer for use in antifungal photodynamic therapy against two human pathogenic fungal species causing skin diseases. This study shows the effect of laser radiation (473 nm) at different powers (25 and 50 mW) and exposure time (5, 10 and 15 min) associated with Lawsonia Inermis L., a natural photosensitizer on the viability of Sporothrix schenkii and Microsporum fulvum. Although inhibition was observed in all the cases, a maximum inhibition of 83% in case of Sporothrix schenckii and 82.49% in case of Microsporum fulvum was achieved when they were exposed for 10 and 15 min respectively with laser (473 nm) power 50 mW. This study is important to optimize different parameters to design a low-cost, compact, non-invasive and portable device for the treatment of superficial and cuteneous skin diseases.