[7a-A503-1~12] 12.6 Nanobiotechnology

[7a-A503-2] Single-molecule discrimination of artificial nucleotides through machine learnings

〇Takahito Ohshiro¹, Takeshi Yoshida¹, Takanori Takatani¹, Takashi Washio¹, Masateru Taniguchi¹ (1.ISIR, Osaka Univ.)

Keywords:DNA, Tunnel-Current, Machine Learning

We performed single-molecule tunnel-current measurements for modified nucleobase solutions and a blank solution with nano-gap electrodes, and machine-learning for each of the conductance-time profiles. By the machine-learning, we found the characteristic noise signals in the profiles and then are removed from the profiles and evaluate the discrimination ability of these nucleotide. We found that, by using the conductance-time signals, the discrimination ability of the modified base species is significantly improved, relative to the conventional discrimination based on the histogram of the electric conductivity.