[14a-F203-1~13] 15.1 Bulk crystal growth

[14a-F203-2] Control of the local strain in subgrains of protein crystals under application of an external electric field

〇Haruhiko Koizumi¹, Satoshi Uda¹, Masaru Tachibana², Kenichi Kojima³, Junpei Okada¹, Jun Nozawa¹ (1.IMR, Tohoku Univ., 2.Yokohama City Univ., 3.Yokohama Soei Univ.)

Keywords:external electric field, protein crystal, strain

In order to allow both structure-guided drug design and controlled drug delivery, it is important to determine the 3D structures of protein molecules. At present, these structures are primarily determined using X-ray diffraction analysis, and therefore high-quality single crystals of proteins with high diffractivity are required, even though these are quite difficult to obtain. In this presentation, we suggest the existence of the local strain in subgrains of protein crystals, and the control of the local strain by applying an external electric field. Moreover, we also discuss the effect of the local strain on diffractivity.