9:30 AM - 11:30 AM
▲ [16a-P2-12] Protonic biotransducer for recording and stimulating enzyme reaction
Keywords:Biotransducer, ion control, enzyme reaction
The quest for smaller and faster computing has mostly focused on controlling the flow of electrons and holes in nanoscale structures. In living systems, ionic and protonic currents affect physiological function. As such, ionic and protonic devices offer exciting opportunities for bioelectronics. Proton transport in nature is important for ATP oxidative phosphorylation in mitochondria, light activated proton pumping in bacteriorhodopsin, and the antibiotic gramicidin. All these systems have in common networks of hydrogen bonds formed by water and biomolecules − proton wires. Protons hop along these wires according to the Grotthuss mechanism. In analogy with dopants in electronic semiconductors, in proton wires acids are H + donors and bases are H+ acceptors to yield H+ and OH- (proton hole) conductors. So far, we presented bioprotonic devices 1-3 with biopolymer H+ and OHconductors such as diodes, complementary transistors, 4 and resistive memories. 5 In this poster session, I will present our recent efforts in integrating these devices with enzyme logic gates, 6 ion channels,7 and optobioprotonic devices. 1 Miyake, T. & Rolandi, M. Grotthuss mechanisms: from proton transport in proton wires to bioprotonic devices. Journal of physics. Condensed matter 28, 023001(2016). 2 Hemmatian, Z. et al. Taking electrons out of bioelectronics: bioprotonic memories, transistors, and enzyme logic. Journal of Materials Chemistry C 3, 6407-6412(2015). 3 Zhong, C. et al. A polysaccharide bioprotonic field-effect transistor. Nat Commun 2, 476(2011). 4 Deng, Y. et al. H+-type and OH--type biological protonic semiconductors and complementary devices. Sci. Rep. 3, 2481(2013). 5 Josberger, E. E., Deng, Y. X., Sun, W., Kautz, R. & Rolandi, M. Two-Terminal Protonic Devices with Synaptic-Like Short-Term Depression and Device Memory. Advanced Materials 26, 4986-4990(2014). 6 Miyake, T., Josberger, E. E., Keene, S., Deng, Y. & Rolandi, M. An enzyme logic bioprotonic transducer. APL Materials 3, 014906 (2015). 7 Miyake, T. et.al. “Proton mediated control of biochemical reactions with bioelectronic pH modulation”, Scientific Reports (Nature), 6, 24080 (2016).