[16p-313-1~12] 8.6 Plasma life sciences

△ [16p-313-2] Metabolomics analysis of glioblastoma incubated with the plasma-activated-medium

〇Naoyuki Kurake¹, Tanaka Hiromasa², Ishikawa Kenji¹, Hashizume Hiroshi², Nakamura Kae³, Kajiyama Hiroaki³, Kikkawa Fumitaka³, Mizuno Masaaki³, Takeda keigo¹, Kondo Hiroki¹, Sekine Makoto¹, Hori Masaru² (1.Nagoya Univ. Eng., 2.Nagoya Univ. Inst. Innovation for Future Society, 3.Nagoya Univ. Med.)

Keywords:non-equilibrium atmospheric pressure plasma, plasma medicine, metabolomics

There are many reports about an antitumor effect of plasma activated medium (PAM). However, the mechanism is unclear. In this study, we focused on Warburg effect, which is an activation of glycolysis in cancer cells, and metabolome of cancer cells were investigated. As a result, glycolysis was down-regulated by the PAM and it might induced by down-regulating of a NAD⁺ synthesis enzyme, NAMPT.