[18a-231B-1~8] 1.6 Ultrasonics

[18a-231B-4] Detection of collagen fibrosis in myocardial infarction through the acoustically stimulated electromagnetic method

〇Kenji Ikushima¹, Wataru Yamaguchi¹, Hisato Yamada¹, Yuji Nakagawa² (1.Tokyo Univ. A&T, 2.TERUMO Corp.)

Keywords:Ultrasonic, Collagen, Piezoelectricity

In organs such as the heart, liver and lung, activated fibroblasts sometimes produce excess collagen and the tissues may become hard. Particularly in myocardial infarction, when myocardial cells are necrosed due to ischemia, collagen accumulation occurs to fill the marks of necrotic cells, and the heart becomes fibrotic. Currently, the gold standard for noninvasively diagnosing fibrosis of myocardial infarction is MRI, but development of a method using ultrasonic waves, which allows easier examination of the pathophysiology of heart failure and prognostic prediction, is desired. The purpose of this study is to visualize collagen fiberization by detecting electromagnetic signals induced by ultrasonic waves. In this talk, the results of two-dimensional and tomographic imaging of the ASEM signal are reported for the rat myocardial infarction model.