[19a-PB1-1~11] 9.5 New functional materials and new phenomena

▼ [19a-PB1-6] Construction of the NaGdF₄:Yb:Tm@Cu core-shell nanoparticles for effective bioimaging and photothermal therapy

〇(DC)MohamedMatharSahib IbrahimKhaleelullah^1,2, Daichi Kuroda³, Asahi Tanaka¹, Wataru Inami^1,2, Yoshimasa Kawata^1,2,3, Yosuke Shimura^2,3, Yasuhiro Hayakawa^1,2,3 (1.GSST, Shizu Univ., 2.RIE, Shizu Univ, 3.Engg., Shizu Univ)

Keywords:bio-imaging, Photo thermal therapy, Core-shell nanoparticles

Near infrared (NIR) active nanostructures with applications in imaging and therapy have attracted significant attention in cancer diagnosis and treatment. NIR active structures can provide molecular images, penetrating from deep within tissue with high resolution. In addition, particles with photothermal properties could lead to a new era of cancer diagnostics. We report the first synthesis of core-shell NaGdF₄:Yb:Tm@Cu (NGF@Cu) nanostructures. NGF@Cu particles have molecular imaging and photothermal activation properties owing to an upconverting core and metallic shell. The upconversion core means that cancer cell location can be recognized and the Cu-based photothermal therapy is subsequently able to disrupt the cells. NGF@Cu characterization studies, including STEM and EDS mapping, confirmed the core-shell structure with Cu as the shell. This study demonstrates the use of a single nanostructure for diagnosis in the NIR therapeutic window (650-1400 nm) and photothermal therapy, with a core-shell particle efficiency of ~36.3 %.