[19p-222-1~12] 12.6 Nanobiotechnology

[19p-222-12] Analysis of intercellular interactions making up a tumor microenvironment by using atomic force microscopy

Kenta Ishibashi¹, Tomoko Okada², Chikashi Nakamura^1,2, 〇Hyonchol Kim^1,2 (1.Grad. Sch. Eng., Tokyo Univ. Agric. Technol., 2.Biomed. Res. Inst., AIST)

Keywords:Atomic force microscopy, Cancer, Adhesion

Contribution of stimulation of macrophage secretion for the change of intercellular adhesion strength of two cancer cells was measured by using atomic force microscopy. In results, the intercellular adhesion forces increased by the stimulation, and in addition, Young's modulus decreased and invasive capacity increased. Moreover, expression of plakoglobin, which is a molecule composed of desmosome junction, increased in cancer cells.