[19p-438-1~19] 3.8 Optical measurement, instrumentation, and sensor

△ [19p-438-12] Microfluidic particle analysis with dual-comb coherent Raman spectroscopy

〇Shigekazu Takizawa¹, Tasuku Nakamura¹, Takuro Ideguchi¹, Miu Tamamitsu¹, Sangwook Lee¹, Kotaro Hiramatsu¹, Venkata Ramaiah¹, Jee-Woong Park¹, Yusuke Kasai³, Takeshi Hayakawa^2,3, Shinya Sakuma³, Fumihito Arai³, Keisuke Goda^1,4,5 (1.Tokyo univ., 2.Chuo univ., 3.Nagoya univ., 4.UCLA, 5.JST)

Keywords:Raman spectroscopy, Dual-comb spectroscopy, Particle analysis

Although microparticles are widely used in medicines and cosmetics, their influence on living organisms and environments have not been fully understood. There has been a great demand for a high-throughput method to analyze the chemical property of each microparticle. While Raman spectroscopy is a promising way to investigate molecular structural information in a label-free manner, its application to large-scale particle analysis has been limited due to its low signal intensity, and consequently, low throughput. In this study, we report the development of a label-free, high-throughput flow particle analyzer based on dual-comb coherent Raman spectrometer.