[20p-PA4-1~23] 12.7 Biomedical Engineering and Biochips

[20p-PA4-14] Binding activity of SGP modified BSA to influenza viruses

〇Toshio Kawahara¹, Hiroaki Hiramatsu¹, Yusuke Ohmi¹, Yasuo Suzuki¹, Kyoko Hayashi¹, Shin-ichi Nakakita², Yohei Watanabe³, Yasuhide Ohno⁴, Kenzo Maehashi⁵, Takao Ono⁶, Yasushi Kanai⁶, Kazuhiko Matsumoto⁶ (1.Chubu Univ., 2.Kagawa Univ., 3.KPUM, 4.Tokushima Univ., 5.TUAT, 6.Osaka Univ.)

Keywords:influenza virus, bio sensor, sugar chain

The spread of influenza A virus variants needs continuous monitoring because of the high mutation rate. Many infections in humans have been reported and this might be due to the potential of these viruses to mutate and result in a change of host from birds to humans. The surveillance of such mutations is essential, and therefore highly sensitive sensor systems are needed. The host change can be observed as a change of the bonding between the virus protein and the host sugar chain. We used sugar chains with different coordinations of terminal sialic acid and penultimate galactose as the detection molecules. For the enhancement of sensitivity, we have developed the distribution control of molecules. Using the bovine serum albumin localization, we have obtained the stable distribution.