[17a-A202-1~8] 12.6 Nanobiotechnology

[17a-A202-1] Control of DNA Translocation through GeSbTe Nanopore by Laser Heating

〇Takaha Mizuguchi¹, Hirohito Yamazaki¹, Yuki Ishikawa¹, Masashi Kuwahara², Toshiharu Saiki¹ (1.Keio University, 2.AIST)

Keywords:nanopore, DNA sensing, thermophoresis

The lower thermal conductivity of chalcogenide glass material Ge₂Sb₂Te₅ is potentially available for generating localized-thermal distribution in a solvent. We previously reported that the thermal property of Ge₂Sb₂Te₅ provided thermal and long-range transportation of polystyrene beads diffused in a 2D micro-fluid channel due to heat convection induced by localized-thermal distribution. A long-range transportation technology has long been desired for biological applications. In this work, we demonstrate a noble application of Ge₂Sb₂Te₅ to a nanopore sensor device. Nanopore is a nano-scaled hole on a thin silicon membrane used as a nano-fluid device. Translocation of proteins and DNA molecules through a nanopore and measuring ionic current blockades or fluorescence signals allows single molecule measurements due to its extremely high spatial resolution. Here, we report that the combination of Ge₂Sb₂Te₅ and nanopore reduced the event rate of DNA translocation by thermal transport called Soret effect while an optical measurement with a lower applied voltage.