[18p-A304-1~6] The synchrotron radiation micro beam technology for the real elucidation of biological effect of radiation

[18p-A304-5] Bystander cellular responses of targeted nuclear or cytoplasmic irradiations by X-ray microbeams generated with synchrotron radiations

〇Masao Suzuki¹, Noriko Usami², Tomoo Funayama³, Yuichiro Yokota³, Michiyo Suzuki³, Yasuhiko Kobayashi³ (1.NIRS, QST, 2.PF, KEK, 3.TARRI, QST)

Keywords:microbeams, bystander effects

The research using a microbeam can provide us very important information in the research field of radiation science and it should be essential for us to understand radio-biological effects, such as bystander effect, genomic instability and radio-adaptive response, induced by low-dose or low-fluence irradiations. We have been studying cellular responses induced by heavy-ion microbeams at the Takasaki Ion Accelerator for Advanced Radiation Application, Takasaki Advanced Radiation Research Institute and X-ray microbeams at the Photon Factory, High Energy Accelerator Research Organization. We report bystander effects induced in the normal human fibroblasts irradiated with the targeted nucleus or cytoplasmic irradiations of the X-ray microbeams.