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△ [19a-B303-1] Investigation of low-fluence photoacoustic spectroscopy for non-invasive blood glucose monitoring
Keywords:photoacoustic, continuous wave
Photoacoustic spectroscopy (PAS) is being investigated for non-invasive blood glucose monitoring owing to its success in in-vivo quantitative measurement. However, the high laser intensity typically required in PAS—pulse energy of 100 mJ over a pulse width of several nanoseconds—requires a large instrument with a complicated configuration. To develop a small and simple PAS system, we investigated PAS using a low-optical intensity laser with pulse energy on the order of 1 mJ. To obtain an acoustic signal with detectable intensity, we employed a long pulse width of over several microseconds. In this paper, we present the resulting acoustic waves generated by various pulse widths and discuss optimizing the pulse width to obtain a maximally intense acoustic signal.