[19a-F306-1~12] 12.7 Biomedical Engineering and Biochips

△ [19a-F306-5] Gold nanoparticle encapsulated molecularly imprinted nanogels as radiation sensitizers to enhance antitumor effects

〇Aoi Yoshida¹, Takuya Yamada¹, Kentarou Kiguchi¹, Hiroaki Akasaka², Ryohei Sasaki², Yukiya Kitayama¹, Toshifumi Takeuchi¹ (1.Grad. Sch. Eng., Kobe Univ., 2.Grad. Sch. Med., Kobe Univ.)

Keywords:molecular imprinting, nanoparticles, radiotherapy

We designed and prepared MIP-NGs containing gold nanoparticles, and tried to apply them as radiosensitizers in radiotherapy. First, gold nanoparticle-encapsulating MIP-NGs were synthesized by using gold nanoparticles as the core and the MIP layer as the shell. As a result of administration of gold nanoparticle-encapsulating MIP-NGs into tumor-transplanted mice and irradiation of X-ray, the tumor progression was suppressed as compared with the case where only radiation irradiation was performed.