[19a-F306-1~12] 12.7 Biomedical Engineering and Biochips

△ [19a-F306-7] Evaluation of hard tissue compatibility of titanium oxide thin films deposited by reactive sputtering

〇Masato Takeuchi¹, Kei Oya^1,2, Kazuki Hosoya², Kenta Hojo², Satoru Iwamori², Takeo Nakano¹ (1.Seikei Univ., 2.Tokai Univ.)

Keywords:reactive sputtering, titanium oxide thin films, hard tissue compatibility

Titanium (Ti) and its oxides are the materials which are known to have excellent biocompatibility. It has been reported that the composition ratio of Ti oxide in the film has strong influence on the cell response. The elucidation of the relationship between the surface characteristics of the material and its biological response should lead to the development of novel Ti based biomaterials. In this study, titanium oxide thin films were deposited by the reactive sputtering technique. To control the ratio of titanium dioxide in the film, we changed the flow rate of the reactive gas (O₂ )during the sputtering. After evaluating for the surface characteristics of the deposited samples, cell culture test was performed to evaluate the cell adhesiveness and bone differentiation ability. While the former was not affected much by the film composition, the later was strongly dependent on the composition in which the superior calcification was observed on the Ti⁴⁺ dominant surface.