The 80th JSAP Autumn Meeting 2019

Presentation information

Oral presentation

12 Organic Molecules and Bioelectronics » 12.7 Biomedical Engineering and Biochips

[18a-E202-1~11] 12.7 Biomedical Engineering and Biochips

Wed. Sep 18, 2019 9:00 AM - 12:00 PM E202 (E202)

Koichiro Miyamoto(Tohoku Univ.), Taira Kajisa(Tokushima Univ.)

11:00 AM - 11:15 AM

[18a-E202-8] Control of anchor monolayer for specific detection of small biomarker

Shogo Himori1, Shoichi Nishitani1, Toshiya Sakata1 (1.Univ. of Tokyo)

Keywords:FET biosensor, Diazonium layer

An artificially well-designed biointerface is required for a new strategy of biosensor such as an enzyme-free glucose sensor. A solution-gate field-effect transistor (FET) is based on the potentiometric measurement of intrinsic ionic or biomolecular charges at the gate surface of the FET without enzymatic reactions. Moreover, an extended-Au film-gate FET enables a highly-sensitive detection of small biomarkers, because the Au film exhibits a strong catalytic action, resulting in the oxidation of organic compounds such as uric acid and glucose. However, the selective detection of small biomarkers, which involves a signal to noise ratio, with the Au film electrode is not sufficient for a real sample containing impurities. In this study, we have designed a Au film/solution interface for the selective detection of small biomarkers and investigated the effect of diazonium monolayer on the prevention of nonspecific signals based on non-targeted small biomarkers.