[18a-E202-1~11] 12.7 Biomedical Engineering and Biochips

△ [18a-E202-8] Control of anchor monolayer for specific detection of small biomarker

〇Shogo Himori¹, Shoichi Nishitani¹, Toshiya Sakata¹ (1.Univ. of Tokyo)

Keywords:FET biosensor, Diazonium layer

An artificially well-designed biointerface is required for a new strategy of biosensor such as an enzyme-free glucose sensor. A solution-gate field-effect transistor (FET) is based on the potentiometric measurement of intrinsic ionic or biomolecular charges at the gate surface of the FET without enzymatic reactions. Moreover, an extended-Au film-gate FET enables a highly-sensitive detection of small biomarkers, because the Au film exhibits a strong catalytic action, resulting in the oxidation of organic compounds such as uric acid and glucose. However, the selective detection of small biomarkers, which involves a signal to noise ratio, with the Au film electrode is not sufficient for a real sample containing impurities. In this study, we have designed a Au film/solution interface for the selective detection of small biomarkers and investigated the effect of diazonium monolayer on the prevention of nonspecific signals based on non-targeted small biomarkers.