4:00 PM - 6:00 PM
▼ [19p-PB9-9] Nanopore sensing in two immiscible electrolytes: current-voltage characteristics between ionic liquid and salt solution
Keywords:nanopore, liquid-liquid interface, ionic liquid
Nanopore sensor has received much attention for widely used as a multi physical reposing detection which offering versatile applications for bio-nanoparticles. Most studies have been performed with nanopore devices under the same electrolyte on both sides of membrane. Nevertheless, salt and viscosity gradients across membranes truly exist in natural world such as cell membrane ion channels. In fact, many researchers reported that solutions gradients have effective improvements of dwell-time and signal-to-noise ratio than implementing in the same electrolyte condition.
In this work, we investigated an immiscible liquid-liquid system across a low-aspect ratio nanopore by introducing aqueous PBS buffer and non-mixable room temperature ionic liquid (BmimPF6). Not only the salt and viscosity gradients producing by ionic liquid, but also the liquid-liquid interface occurred by the immiscible two phases. Observing electrophoresis between two phases system in nanopores may further our understanding of ions transport through biological ion channels and nanoscale electroosmotic flow at the contact surface. These promising results indicate new important mechanism to extend particle translocation time in nanopore even make a trap because of the force of drag and surface tension. liquid-liquid interface in nanopore would offer a new platform to explore novel physics in the research areas of both nanoscale fluidics and nanobiotechnology.
In this work, we investigated an immiscible liquid-liquid system across a low-aspect ratio nanopore by introducing aqueous PBS buffer and non-mixable room temperature ionic liquid (BmimPF6). Not only the salt and viscosity gradients producing by ionic liquid, but also the liquid-liquid interface occurred by the immiscible two phases. Observing electrophoresis between two phases system in nanopores may further our understanding of ions transport through biological ion channels and nanoscale electroosmotic flow at the contact surface. These promising results indicate new important mechanism to extend particle translocation time in nanopore even make a trap because of the force of drag and surface tension. liquid-liquid interface in nanopore would offer a new platform to explore novel physics in the research areas of both nanoscale fluidics and nanobiotechnology.