[20a-E313-1~10] 3.4 Biomedical optics

[20a-E313-9] Volumetric data restoration of inner ear sensory epithelia based on sparse modeling with multifrequency swept optical coherence microscope

〇(PC)Samuel Choi^1,3, Shogo Muramatsu^1,3, Takeru Ota^2,3, Fumiaki Nin^2,3, Takamasa Suzuki¹, Hiroshi Hibino^2,3 (1.Faculty of Eng., Niigata Univ., 2.School of Medicine, Niigata Univ., 3.AMED-CREST, AMED)

Keywords:Optical coherence microscope, Sparse Modeling, optical comb

A multifrequency swept optical coherence microscope was developed to visualize the vibrational distribution and structure of the inner ear sensory epithelium of living animals in a wide field of view. This system obtains a three-dimensional tomographic image by capturing en-face interference images along the depth direction. However, the resulting data includes diffused reflections such as speckles, motion artifacts due to the living sample, and wavelength aberrations in the microscope. In this research, to remove these noise components efficiently, a sparse model assuming a latent refractive index distribution and non-separable oversampled lapped transform were applied as a synthesis dictionary to the measured in-vivo data. Three-dimensional data restoration was successfully demonstrated by this approach.