[9p-S421-1~16] 12.7 医用工学・バイオチップ

▼ [9p-S421-4] Implantable micro-imaging device for visualizing neural activity in regions related to feeding behavior

〇(M2)Mark Guinto¹、Yasumi Ohta¹、Mamiko Kawahara¹、Makito Haruta¹、Toshihiko Noda²、Kiyotaka Sasagawa¹、Takashi Tokuda¹、Jun Ohta¹ (1.NAIST、2.Toyohashi Univ. Tech.)

キーワード：fluorescence imaging, implantable devices, GCamP6

Feeding behavior results from a complex interplay between multiple control systems spanning neural circuits that are known to be involved in the processing of reward and pleasure. Currently, visualizing neural activity from calcium dynamics in the deep brain area remains difficult to implement without influencing the behavior of an awake mouse. To this end, we have developed an implantable micro-imaging device that can visualize neural activity from calcium dynamics in the deep brain [1]. Compared to extant imaging systems, advantages in our design include: (1) reduced invasiveness due to its streamlined needle-like design, (2) fluorescence measurements under the freely moving condition with minimum stress because of the light weight (~0.02 g), and (3) simultaneous implantability at multiple points for the study of neuronal networks due to the miniaturization. In the presentation, we will report a measurement of feeding behavior by applying the device and show successful results from the experiments.
[1] J. Ohta et al., Proc. IEEE, 105(1), 158, 2017.