[8p-Z15-1~5] Optical functions of thin films studied by various quantum beams

[8p-Z15-3] Ultra-Small Fluorescent Metallic Nanomaterials for Biomedical Imaging

〇Shin-ichi Tanaka¹ (1.NIT(KOSEN)-Kure)

Keywords:Platinum nanoclusters, Fluorescent probe, Biomedical application

Noble-metal nanoclusters (Au, Ag and Pt) consisting of several atoms have been applied for advanced biological application in sensing, cellular imaging, and biomedicine owing to their excellent physicochemical properties and biocompatibility, such as smaller size, less cytotoxicity, tunable fluorescence emission and high photostability. Our recent studies demonstrated that fluorescent Pt nanoclusters possessed low cytotoxicity, ultrasmall size, excellent photostability, and high brightness, and could be utilized as a fluorescent probe for highly sensitive optical imaging of cancer on both the cellular and the animal level. In this presentation, we report the synthesis of such Pt nanoclusters and their characterization and capability for cellular and in vivo imaging. The synthesized Pt nanoclusters exhibited from blue to near-infrared emission (Em = 470 to 820 nm). After labeling the MDA-MB-231 cells (breast cancer) with Pt nanoclusters, we obtained the fluorescent image of single living cells. Our luminescent Pt nanoclusters promise to be a useful fluorescent probe for in vivo imaging and biomedical application.