Keywords:terahertz, allergy, histamine
The number of people with allerguc diseases is increasing due to changes in our living enviroment and diet. As conventional methods, an IgE antibody test and a histamine release test are available for allergic materials for diagnoses. These methods are minimally invasive because they can be tested only by collecting blood. However, Positive results for the IgE antibody test sometimes do not show allergen reactions. On the other hand, histamine release test directly measures histamine, which can be produced by allergen reactions so that the results can be connected to the allergic symptoms. However, few measurable allergens are available for the histamine release test.
In our group, the concentration of histamine in solution was measured by using a terahertz chemical microscope (TCM) . We succeeded that it was detected by using histamine antibody previously. In this study, we tried measuring histamine concentration in solution with histamine H1 receptor as the ligand, which can be expected to measure histamine with higher selectivity.