[13p-A407-1~16] 12.6 Nanobiotechnology

[13p-A407-14] Molecularly imprinted nanogels with dansylamide groups as interaction sites for human serum albumin capable of regulating protein corona

〇Takahiro Morishita¹, Aoi Yoshida¹, Natsuki Hayakawa¹, Kentaro Kiguchi¹, Yukiya Kitayama¹, Toshifumi Takeuchi¹ (1.Grad. Sch. Eng., Kobe Univ.)

Keywords:molecular imprinting, protein corona, albumin

Molecularly imprinted polymer nanogels (MIP-NGs) possessing dansylamide groups as interaction sites for human serum albumin (HSA) were prepared by the precipitation polymerization for regulating protein corona. The affinity and selectivity toward HSA of MIP-NGs were evaluated by isothermal titration calorimetry. Furthermore, protein corona formed on the MIP-NGs in human plasma was investigated by SDS-PAGE.