2:15 PM - 3:00 PM
[14p-D411-2] Highly sensitive magnetic measurement systems using superconducting devices and their applications
Keywords:superconducting quantum interference device, magnetometer, magneto-immunoassay
Highly sensitive magnetometers that detect the weak magnetic characteristics of biological materials using HTS-SQUID have been developed for other clinical and biological applications.The hybrid-type magnetometer performs three functions (VSM, relaxation measurement, and third-harmonic signal analysis) was developed. Aqueous mixtures of ethanol as solvent have been widely investigated. As the solvent concentration changes, the magnetic moment slightly deviates from the characteristics expected by considering the magnetic moment ratio between water and ethanol, solvent concentration, and volume-reducing rate. This difference is attributed to the clustering of the structure rather than a simply mixed uniform structure. A recent liquid-phase immunoassay method is able to detect the third-harmonic signals of MNPs by an HTS magnetometer. This method successfully detected C-reactive protein (CRP), a marker of inflammation, without a washing step that separates the bound and free markers. In addition, the reaction time of CRP was shortened by a magnetic shaking treatment.