[10p-N207-1~16] 12.6 Nanobiotechnology

[10p-N207-13] Coalescence of liposomes

〇Michio Niwano¹, Masato Yamaguchi¹, Kazuki Iwata¹, Teng Ma², Maki Komiya³, Daisuke Tadaki³, Ayumi Hirano-Iwata^2,3 (1.Tohoku Fukushi Univ., 2.AIMR,Tohoku Univ., 3.RIEC, Tohoku Univ./)

Keywords:Liposome, size distribution, coalescence

We prepared liposomes with a diameter of 100 nm and investigated how the particle size of the liposomes changed with time using the nanoparticle tracking analysis (NTA) method. As a result, it was found that the particle size was discrete and that the discrete size increased by a factor of √2. This characteristic particle size distribution is the same as that observed in the coalescence of nanobubbles, and can be interpreted as a result of the fact that liposomes of the same particle size tend to coalesce with each other.