[10p-N207-1~16] 12.6 Nanobiotechnology

[10p-N207-3] Nanopore electrical tweezer for translocation dynamics control

〇Makusu Tsutsui¹, Sou Ryuzaki⁴, Kazumichi Yokota², yuhui He³, Takashi Washio¹, Kaoru Tamada⁴, Tomoji Kawai¹ (1.Osaka University, 2.AIST, 3.Huazhong Univ., 4.Kyushu Univ.)

Keywords:nanoporeq, nanofluidics, elctrophoresis

Translocation dynamics control has long been a critical issue in a practical use of solid-state nanopores for bioanalytical applications such as single-molecule protein analysis and sequencing by ionic current. In the present study, a novel approach to retard the motions of objects in a nanoscale conduit is demonstrated. It consists of a nanopore surround by a platinum ring that serves as a gate electrode to modulate the surface charge density at the wall. The associated change in the electroosmotic flow was found useful to slowdown the translocation time of virus-sized nanoparticles by a factor of 10000.