[16p-Z22-1~15] 12.7 Biomedical Engineering and Biochips

[16p-Z22-9] Change to influenza virus infectivity by difference of gangliosides expression.

〇Hiroaki Hiramatsu¹, Vyankatesh Kudkyal¹, Kyoko Hayashi¹, Yusuke Ohmi¹, Shin-ichi Nakakita², Yohei Watanabe³, Takao Ono⁴, Yasushi Kanai⁴, Kazuhiko Matsumoto⁴, Toshio Kawahara¹ (1.Chubu Univ., 2.Kagawa Univ., 3.KPUM, 4.ISIR, Osaka Univ.)

Keywords:biosensor

Influenza virus transmitted through the sugar-chains on the cell membrane. Here, we focused on gangliosides, which are glycolipids present on the cell membrane, and investigated influenza virus infection using astrocytes established from transgenic mice that induce ganglioside synthesis abnormalities.
The results provided data suggesting that gangliosides do not affect the expression of viral receptor sugar-chains, but regulate any step in viral replication.