9:30 AM - 11:30 AM
[20a-P05-4] Measurement of mechanical properties of epithelial cell sheets by pulsed force mode atomic force microscopy
Keywords:pulsed force atomic force microscopy, epithelial cell sheet
In epithelial cell monolayer, cells interact with the neighboring cells through mechanical
cues. However, the detailed mechanism of cell mechanical interactions remains unknown.
In this study, we succeeded in probing epithelial cell sheets with pulsed-force mode atomic force microscopy (PFM-AFM) with a wide range of scanners at a high spatial resolution. We will present the spatial distribution of rheological properties of cell sheets by analyzing approach retract force curves obtained with PFM-AFM and discuss intrinsic rheological interactions among cells.
cues. However, the detailed mechanism of cell mechanical interactions remains unknown.
In this study, we succeeded in probing epithelial cell sheets with pulsed-force mode atomic force microscopy (PFM-AFM) with a wide range of scanners at a high spatial resolution. We will present the spatial distribution of rheological properties of cell sheets by analyzing approach retract force curves obtained with PFM-AFM and discuss intrinsic rheological interactions among cells.