[20p-A106-2~13] 8.4 Plasma life sciences

△ [20p-A106-4] Selective-Inactivation Effect of Nitrogen-Oxygen-Radical-Activated Lactate Ringer’s Solution on Breast Cancer Cells

〇Taiga Nishida¹, Naoyuki Iwata², Tomiyasu Murata¹, Hiromasa Tanaka², Masaru Hori², Masafumi Ito¹ (1.Meijo Univ., 2.Nagoya Univ.)

Keywords:radical, breast cancer cell, inactivation

Plasma-activated lactate Ringer's solution (PAL) has been reported to be able to selectively inactivate various cancer cells. However, it has not been clarified which factors in plasma contribute production of cytotoxicity effects in PAL. Therefore, we have evaluated contributions of electrically neutral radicals in plasma on selective cytotoxicity of PAL. We prepared nitrogen-oxygen-radical-activated lactate Ringer's solution (NORAL) using a non-equilibrium atmospheric pressure radical source. Prepared NORAL showed selective cytotoxicity on breast cancer comparing to normal cell with certain dilution ratios.