13:30 〜 14:00
▲ [20p-C205-1] [INVITED] Deep optical imaging within complex scattering media
キーワード：Optical microscopy, Imaging through scattering media, Deep-tissue imaging
Optical imaging has played a crucial role in understanding the physiology of living specimens due to its high spatial resolution, molecular specificity, and minimal invasiveness. However, its working depth has been extremely shallow fortissue imaging, and many important reactions occurring deep inside living specimens have still been out of reach as a consequence. The main problem originates from multiple light scattering induced by inhomogeneous tissues, which severely obscures the image information.
Over the past decade, my group has exploited physics governing multiple light scattering to achieve imaging depth beyond the conventional limit. In particular, we developed methodologies based on the deterministic measurement and/or control of multiply scattered waves rather than their stochastic and statistical treatments. In this talk, I will overview some of our recent advancements in deep-tissue adaptive optical microscopy and introduce a key ongoing study investigating the early myelination process in a living mouse brain with its skull intact. In addition, I will talk about the combination of the developed microscopy with other imaging modalities such as single-molecule localization microscopy, which led to the realization of deep-tissue super-resolution imaging. We hope that all these developments will serve as the next-generation tools for biology and medicine.
Over the past decade, my group has exploited physics governing multiple light scattering to achieve imaging depth beyond the conventional limit. In particular, we developed methodologies based on the deterministic measurement and/or control of multiply scattered waves rather than their stochastic and statistical treatments. In this talk, I will overview some of our recent advancements in deep-tissue adaptive optical microscopy and introduce a key ongoing study investigating the early myelination process in a living mouse brain with its skull intact. In addition, I will talk about the combination of the developed microscopy with other imaging modalities such as single-molecule localization microscopy, which led to the realization of deep-tissue super-resolution imaging. We hope that all these developments will serve as the next-generation tools for biology and medicine.